解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Antipituitary antibody (APA) has been reported to be detected in patients with autoimmune thyroid disease. Type 2 iodothyronine deiodinase (D2) is expressed in both pituitary gland and thyroid gland. We studied the association of APA and D2 peptide antibody in patients with autoimmune thyroid disease. Rat pituitary gl...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.52.691
更新日期:2005-12-01 00:00:00
abstract::The mechanisms of paradoxical TRH response in human somatotroph adenoma cells were investigated using intracellular calcium measurement and static incubation assay. Intracellular calcium measurement revealed that TRH induces a biphasic response: a transient increase followed by a sustained plateau. The transient phase...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.52.763
更新日期:2005-12-01 00:00:00
abstract::The serum T3 to T4 ratio is a useful indicator for differentiating destruction-induced thyrotoxicosis from Graves' thyrotoxicosis. However, the usefulness of the serum free T3 (FT3) to free T4 (FT4) ratio is controversial. We therefore systematically evaluated the usefulness of this ratio, based on measurements made u...
journal_title:Endocrine journal
pub_type: 杂志文章,多中心研究
doi:10.1507/endocrj.52.537
更新日期:2005-10-01 00:00:00
abstract::Somatostatin is well known to inhibit the hormone secretion of various peptides. This action has been considered to be generally mediated via six different specific somatostatin receptors (sstr), sstr1, sstr2A, sstr2B, sstr3, sstr4, and sstr5. It then becomes very important to demonstrate the localization of these sst...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.52.605
更新日期:2005-10-01 00:00:00
abstract::Decreased circulating levels of adiponectin, a novel adipose-derived adipocytokine, in obesity possibly contribute to the development of insulin resistance which is a major factor in the pathogenesis of type 2 diabetes. The present study was conducted to examine whether circulating and adipose tissue adiponectin level...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.52.427
更新日期:2005-08-01 00:00:00
abstract::Defects in insulin receptor function have been associated with insulin resistant states such as obesity and type 2 diabetes mellitus. Several types of mutations in the insulin receptor gene have been identified in patients with genetic syndromes of extreme insulin resistance. We have studied a 10-year-old Japanese gir...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.52.499
更新日期:2005-08-01 00:00:00
abstract::This study investigates whether the plasma brain natriuretic peptide (BNP) level is increased by the clinical traits of diabetes, including its complications, and whether these levels are affected by the presence of other combined diseases such as hypertension, hyperlipidemia, and coronary heart disease (CHD) in patie...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.52.353
更新日期:2005-06-01 00:00:00
abstract::Leptin is considered to play a role in maintenance of energy balance and body weight by neuroendocrine mechanisms. The physiological mechanisms for thyroid hormone-induced alteration in serum leptin are not well known. In the present study, the relationship between thyroid hormones and leptin levels was investigated i...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.52.213
更新日期:2005-04-01 00:00:00
abstract::The octanoylation of Ser3 is essential for the biological function of ghrelin. We examined the concentrations of the n-octanoylated active-form ghrelin in cord and neonatal blood using an RIA system that specifically recognized n-octanoylated ghrelin, as well as a system that measured the total ghrelin concentration. ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.52.271
更新日期:2005-04-01 00:00:00
abstract::Thyrotropin-releasing hormone (TRH)-stimulated thyroid stimulating hormone (TSH) response in normal subjects is suppressed by oral glucose administration. Pharmacologic studies indicate that this suppressive action of glucose is mediated by an increase in hypothalamic somatostatin (SRIH) tone. Since activation of the ...
journal_title:Endocrine journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1507/endocrj.52.69
更新日期:2005-02-01 00:00:00
abstract::Metabolic syndrome is a common disorder in Taiwan. For this study 431 subjects were randomly selected from visitors to the Department of Health Management. Blood pressure, blood glucose, lipid, uric acid levels and anthropometric measurements with immunoreactive insulin (IRI) and leptin levels were all correlated. We ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.52.139
更新日期:2005-02-01 00:00:00
abstract::The present study investigated the diurnal variation in GH receptor (GHR) mRNA in liver and skeletal muscle of 3-month-old GH-deficient and -sufficient mice using quantitative real-time RT-PCR. lit/lit (GH deficient) or lit/+ (GH sufficient) mice were fed ad libitum and lights were on between 0600 and 2000. Tissues we...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.51.529
更新日期:2004-12-01 00:00:00
abstract::The purpose of this study was to determine whether polycystic ovary syndrome (PCOS) and nonclassic 21-hydroxylase deficiency (CAH) are related to hyperhomocysteinemia, and to investigate if there is a correlation between homocysteine levels and insulin sensitivity in women with PCOS and CAH. Fifty patients with PCOS, ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.51.601
更新日期:2004-12-01 00:00:00
abstract::The purpose of the study was to evaluate the plasminogen activator inhibitor-1 (PAI-1) levels and PAI-1 activity in young and lean women with PCOS and to compare with controls matched for age and weight. Thirty two women with PCOS and 25 weight and age-matched healthy controls participated in this study. Patients were...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.51.467
更新日期:2004-10-01 00:00:00
abstract::We demonstrated severe hyponatremia in a 68 year-old man who had pituitary tumor. He had poor appetite and was disoriented. Tests revealed hyponatremia of 110 mmol/l, and he was admitted to Jichi Medical School Omiya Medical Center to undergo further tests. Physical findings revealed disturbance of consciousness with ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.51.435
更新日期:2004-08-01 00:00:00
abstract::Circulating human GH (hGH) consists of several molecular isoforms. It was previously reported that the proportion of 20 kilodalton hGH (20K-hGH) was elevated in the serum of patients with active acromegaly. In this study, we investigated the effects of octreotide and transsphenoidal adenomectomy on the proportion of 2...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.51.343
更新日期:2004-06-01 00:00:00
abstract::Although gonadal estrogens are known to facilitate the development of skeletal lesion in SHOX haploinsufficiency, controversy exists as to whether gonadal estrogens are disadvantageous to pubertal growth. To clarify this matter, we analyzed growth pattern in 31 Japanese patients with a normal karyotype and molecularly...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.51.197
更新日期:2004-04-01 00:00:00
abstract::The objective of this study was to investigate the effect of administration of recombinant human growth hormone (hGH) in patients with Noonan syndrome. hGH was administered (0.5 IU/kg/week) to 15 patients with Noonan syndrome over a 2 year period. Average patient age prior to therapy was 7.5 +/- 2.5 (mean +/- SD) yr, ...
journal_title:Endocrine journal
pub_type: 临床试验,杂志文章
doi:10.1507/endocrj.51.61
更新日期:2004-02-01 00:00:00
abstract::A previous study reported a high prevalence of autoantibodies to alpha-enolase in lymphocytic hypophysitis and these antibodies efficiently distinguished lymphocytic hypophysitis from pituitary tumors. To confirm this, we examined autoantibodies to alpha-enolase in patients with lymphocytic hypophysitis (n = 17), pitu...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.50.697
更新日期:2003-12-01 00:00:00
abstract::We describe a patient with right adrenal tumor detected incidentally. The tumor was diagnosed as pheochromocytoma by endocrinological and radiological studies, and was removed surgically. Graves' disease, which had been in remission for more than two decades after discontinuation of antithyroid drug treatment, relapse...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.50.767
更新日期:2003-12-01 00:00:00
abstract::We have developed a new test for estimating the secretory capacity of parathyroid hormone (PTH) from the parathyroid gland. Sodium bicarbonate solution [8.4% (w/v); 35 ml/m(2) body surface area] was infused for 2 min, and blood samples for the determination of plasma ionized calcium, plasma PTH (intact, midregion, car...
journal_title:Endocrine journal
pub_type: 临床试验,杂志文章
doi:10.1507/endocrj.50.545
更新日期:2003-10-01 00:00:00
abstract::To evaluate the clinical usefulness of serum soluble Fas (sFas) and sFas ligand as a prognostic factor and for monitoring the regression and progression of metastatic prostate cancer treated with endocrine therapy, sFas and sFas ligand were measured in sera collected from 30 patients with untreated metastatic prostate...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.50.629
更新日期:2003-10-01 00:00:00
abstract::Treatment plan for neonates with borderline hypothyroidism (persistent hyperthyrotropinemia with normothyroxinemia) has not been established. In this study, changes in thyroid function after discontinuation of low-dose L-thyroxine (L-T4) supplement in infants with the condition were evaluated. Fourteen infants with hy...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.50.379
更新日期:2003-08-01 00:00:00
abstract::Total thyroidectomy was performed in 455 patients with differentiated thyroid carcinoma between 1978 and 1999. Serum calcitonin (CT) was determined preoperatively in all patients using polyclonal antibodies. Among the subjects, 25 patients showed elevated serum calcitonin levels preoperatively. Pathological diagnoses ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.50.453
更新日期:2003-08-01 00:00:00
abstract::Components of cyclinD1/cyclin-dependent kinase 4 (CDK4)/p16INK4a/pRb pathway are the frequent target of many tumor types. We examined the role of retinoblastoma susceptibility gene (RB1) and the CDK4 gene in human pituitary tumorigenesis. For the RB1 gene, pRb expression and loss of heterozygosity (LOH) on 13q in pitu...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.50.309
更新日期:2003-06-01 00:00:00
abstract::There are two local subtypes of extravillous trophoblast (EVT): one is the proliferative phenotype of EVT, which primarily consists of proximal cells and the other is the invasive phenotype of EVT, which is composed mainly of distal cells of cell columns. The mechanism of invasion of EVT to the decidua remains obscure...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.50.199
更新日期:2003-04-01 00:00:00
abstract::This study investigates whether urinary levels of pentosidine, pyrraline and acrolein adduct are increased in type 2 diabetes (DM), and whether these levels are correlated with glycemic control and clinical traits. Urinary levels of pentosidine, pyrraline and acrolein adduct in DM patients (n = 100) recruited from the...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.50.61
更新日期:2003-02-01 00:00:00
abstract::Growth hormone (GH) is known to accelerate spermatogenesis and maintain gonadal function. In this study, we evaluated the effect of GH on recovery from testicular damage induced by cyclophosphamide (CP). Eleven- to fourteen-week-old GH-deficient Lewis rats (dw/dw) were divided into 4 groups (n = 10 each), with one gro...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.49.611
更新日期:2002-12-01 00:00:00
abstract::The presence of human progesterone receptor (PR) mRNA variants has been demonstrated in uterine endometrium and breast tissues as well as in cancer cells of these tissues. While exon deletions by the alternative splicing in these variants have been reported, there are few reports available on the PR mRNA variants with...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.49.473
更新日期:2002-08-01 00:00:00
abstract::Immunocytochemical staining and cell immunoblot assay (CIBA) were performed in adenoma tissue from five patients with Cushing's disease and three patients with clinically silent corticotroph adenomas. All five patients with Cushing's disease showed hypersecretion of ACTH (130, 190, 331, 120, and 130 pg/ml), high level...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.49.285
更新日期:2002-06-01 00:00:00
abstract::Insulin-like growth factor-I activates a calcium-permeable cation channel GRC (growth factor-regulated channel). In the present study, we investigated the immunohistochemical localization of GRC in human tissues using a polyclonal anti-GRC antibody. Immunoreactive GRC was detected in the stomach, duodenum, large intes...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.49.349
更新日期:2002-06-01 00:00:00
abstract::Sexual differentiation of the rodent brain is recognized to involve transcriptional activation of multiple genes induced by gonadal steroids at developmental stages. To identify the genes differing in expression level between sexes, we analyzed gene expression in male and female rat hypothalami at postnatal day 5 by m...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.49.131
更新日期:2002-04-01 00:00:00
abstract::Although subacute thyroiditis (de Quervain's thyroiditis) is presumed to be caused by a viral infection, only 2 familial occurrences of subacute thyroiditis have been reported in the literature. Typical and severe subacute thyroiditis was diagnosed in an older sister who was hospitalized for 8 days. During this period...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.49.207
更新日期:2002-04-01 00:00:00
abstract::Triple A syndrome, also known as Allgrove syndrome, is a rare autosomal recessive disorder characterized by adrenal insufficiency, achalasia and alacrima. It has recently been reported that this syndrome is caused by mutations in the AAAS gene. In the present study, we analyzed the AAAS gene in a Japanese patient with...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.49.49
更新日期:2002-02-01 00:00:00
abstract::We previously developed a radioreceptor assay which is presumably specific for detection of blocking-type anti-TSH receptor (TSHR) antibodies using unsolubilized porcine TSHR. Employing this assay, we measured blocking TSH-binding inhibitory immunoglobulin (TBII) in the sera from 30 untreated Graves' patients and comp...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.48.703
更新日期:2001-12-01 00:00:00
abstract::Ovarian 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD), which converts progesterone to a derivative devoid of biological activity, plays a crucial role in achieving the short estrous cycle in rats. Although 20alpha-HSD activity has also been demonstrated in the thymus, its molecular nature, function, and regulatio...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.48.557
更新日期:2001-10-01 00:00:00
abstract::The effects of an aqueous extract of Ferula hormonis on social aggression, fertility and some physiological and biochemical parameters were investigated in male mice. The ingestion of 3 mg/kg of aqueous extract of F. hormonis for six weeks clearly inhibited social aggression. Body wet weight and other sex accessory or...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.48.473
更新日期:2001-08-01 00:00:00
abstract::Transsphenoidal adenomectomy is currently the first choice for treatment of patients with pituitary ACTH-dependent Cushing's syndrome. However, pharmacotherapy is prescribed for some patients, e.g., unsuccessful surgery. We treated a woman in whom pituitary Cushing's syndrome was improved while she was on antimuscarin...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.48.303
更新日期:2001-06-01 00:00:00
abstract::The aim of this study was to assess the effect of the long-term different diabetic therapies on the plasma leptin level in type 2 diabetic subjects. We measured plasma leptin, body fat and fasting plasma insulin in 96 type 2 diabetic male subjects. They had received the same treatment regimen for more than one year (3...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.48.377
更新日期:2001-06-01 00:00:00
abstract::Kallmann syndrome is defined by the association of hypogonadotropic hypogonadism and anosmia. The KAL1 gene is responsible for the X-linked form of Kallmann syndrome. We analyzed the KAL1 gene in 19 Japanese patients with Kallmann syndrome, including 3 patients reported previously, using PCR-direct sequencing method. ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.48.143
更新日期:2001-04-01 00:00:00